Long-term sensorimotor and memory impairment after transient middle cerebral artery occlusion in rats: Special reference to free radical scavenger
نویسندگان
چکیده
منابع مشابه
Research Paper: Optimization of Transient Focal Cerebral Ischemia Model by Middle Cerebral Artery Occlusion
Introduction: Cerebral ischemia is one of the most common causes of death in human populations in the industrial communities. The need for animal models is inevitable to study the pathophysiology and treatment of cerebral ischemia in human. The current study aimed at evaluating the strengths and weaknesses of different techniques used to create ischemia in previous studies and optimizing the tr...
متن کاملA comparison of long-term functional outcome after 2 middle cerebral artery occlusion models in rats.
BACKGROUND AND PURPOSE Proven behavioral assessment strategies for testing potential therapeutic agents in rat stroke models are needed. Few studies include tasks that demand higher levels of sensorimotor and cognitive function. Because behavioral outcome and rate of recovery vary among ischemia models, there is a need to characterize and compare performance on specific tasks across models. M...
متن کاملLong-term spatial cognitive impairment after middle cerebral artery occlusion in rats: no involvement of the hippocampus.
The behavioral and neurochemical changes in the chronic phase of permanent occlusion of the right middle cerebral artery (MCA) in rats were investigated. One month after MCA occlusion, 23 rats were unable to solve a radial eight-arm maze task during an entire 1-month period, whereas seven rats were able to solve this task. Three months after occlusion, 19 MCA-occluded rats failed to solve the t...
متن کاملRecovery of sensorimotor function after distal middle cerebral artery photothrombotic occlusion in rats.
BACKGROUND AND PURPOSE The purpose of the present study was to delineate the behavioral correlates of focal thrombotic occlusion of the distal middle cerebral artery in rats and to compare the pattern of deficits and subsequent recovery to that following proximal middle cerebral artery occlusion. METHODS Ten Sprague-Dawley rats underwent photothrombotic occlusion of the distal middle cerebral...
متن کاملDalfampridine improves sensorimotor function in rats with chronic deficits after middle cerebral artery occlusion.
BACKGROUND AND PURPOSE Stroke survivors often have permanent deficits that are only partially addressed by physical therapy. This study evaluated the effects of dalfampridine, a potassium channel blocker, on persistent sensorimotor deficits in rats with treatment initiated 4 or 8 weeks after stroke. METHODS Rats underwent permanent middle cerebral artery occlusion. Sensorimotor function was m...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1999
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)34987-x